You, Me and Dupree is a 2006 American romantic comedy film directed by Anthony Russo and Joe Russo and written by Mike LeSieur. It stars Owen Wilson, Kate Hudson, Matt Dillon, Seth Rogen, Amanda Detmer, Todd Stashwick and Michael Douglas.
The film revolves around newlyweds Carl and Molly Peterson (Dillon and Hudson). After Carl's best man and friend Randolph Dupree (Wilson) loses his job and apartment, the couple allow him to move in but Dupree inevitably overstays his welcome.