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The Devil Commands is a 1941 American horror film directed by Edward Dmytryk and starring Boris Karloff, Amanda Duff and Richard Fiske. The working title of the film was The Devil Said No. In it, a man obsessed with contacting his dead wife falls in with a sinister phony medium. The Devil Commands is one of the many films from the 1930s and 1940s in which Karloff was cast as a mad scientist with a good heart. It was one of the last in line of the low-budget horror films that were produced before Universal Studios' The Wolf Man. The story was adapted from the novel The Edge of Running Water by William Sloane.