Mr. & Mrs. Smith may refer to:
Mr. & Mrs. Smith (1941 film), an American comedy directed by Alfred Hitchcock
Mr. & Mrs. Smith (2005 film), an American action-comedy film starring Brad Pitt and Angelina Jolie
Mr. & Mrs. Smith (1996 TV series), a short-lived American series airing on the CBS network in 1996
"Mr and Mrs Smith", a song by Stereophonics on their 2015 album Keep the Village Alive
