A trio of young scientists from the city head out into the countryside to investigate a source of uranium at the base of a sacred mountain. On their way, they carelessly destroy a roadside shrine and run over and kill a dog belonging to a local boy. The boy puts a curse on them and tries to disrupt the wedding when a local girl, Reiko, marries one of the trio.
Back in the city, the newlyweds are subjected to a string of increasingly disturbing and inexplicable happenings and Reiko slowly goes insane, convinced that her husband has been cursed and that she has been possessed by the spirit of the Dog God. An attempt to exorcise her ends in tragedy when she dies during the ceremony. One of the trio of scientists throws himself off a skyscraper and a second member of the group is fatally attacked by a pack of feral dogs. But these terrible events are only the start of the CURSE OF THE DOG GOD.