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Columbia's Two-Man Submarine was predicated on a then-new Japanese invention, designed to maneuver in waters where no normal-sized sub could go. Naturally, the Japanese themselves could not be the heroes of this 1944 film, so Tom Neal and Lloyd Bridges play the good guys, while ersatz Nipponese-like Abner Biberman and George Lynn were the villains. The plot concerns Axis efforts to steal the secret of a revolutionary new drug, which is being developed on a remote South Pacific island. The Japanese utilize a two-man sub to infiltrate the island, but the Americans rather unconvincingly turn the tables on them in the last reel. Ann Savage, Tom Neal's future vis-a-vis in Detour, provides the largely unnecessary female interest.