Tarzan (Johnny Weissmuller) must once more contend with outsiders who invade his jungle domain to hunt for gold. Guarding the valuable ore is a tribe of hostile Amazons, led by Maria Ouspenskaya. The Amazons regard every man as their enemy, and very nearly kill Tarzan before he can rescue them from the villains. Also in the cast are Brenda Joyce as a blonde Jane, Johnny Sheffield as Boy, Barton MacLaine as the principal heavy, and "cult" horror star Aquanetta as an Amazon maiden. Tarzan and the Amazons was Johnny Weissmuller's ninth appearance as the Lord of the Apes.