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Harry D'Abaddie D'Arrast, one of the busiest of Hollywood's Ernst Lubitsch imitators, warmed the director's chair for Serenade. Adolphe Menjou is cast as Franz Rossi, a brilliant composer blessed with a beautiful wife, Gretchen (Kathryn Carver). For reasons that defy explanation, Rossi insists upon "playing the field" with other women, and this is why he endeavors to keep Gretchen at home and away from his "work." Eventually, however, Gretchen finds out what her husband has been up to, whereupon she completely disappears from view. Following a thin (and carefully planted) trail of clues, Rossi catches up with his wife at a fancy hotel, where all evidence points to the possibility that Gretchen herself is enjoying the favors of a gentleman caller. What he doesn't know is that Gretchen has stage-managed a phony liaison to teach her errant husband a lesson.