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Two actors who owe their entire careers to the western genre seek revenge against a legendary screenwriter who once mistreated them on the set of an early film in this eclectic send-up of The Searchers from Repo Man director Alex Cox. Mel and Fred have been acting in westerns since as far back as either man can remember, but the one thing they recall above all is the terrible mistreatment they suffered as children while working on the film "Buffalo Bill vs. Doc Holliday." In those days, celebrated screenwriter Fritz Frobisher seemed more like a real-life monster than a master storyteller, and seemed steadfast in his determination to make the two child actors suffer as much as humanly possible. While chances are good that Frobisher has long forgotten his fateful transgression, Mel and Fred have been harboring their bitter grudge for years now. One day, the vengeful duo discover that Frobisher is set to make a personal appearance at a special movie screening in Monument Valley - the very sight where John Ford's famous westerns were filmed - and eagerly begin packing their bags for the ultimate revenge road trip. Despite the fact that Mel and Fred have been waiting for this day since the last time they set eyes on the sadistic scribe, things suddenly take an unexpected turn that leave the fate of all involved hanging on their knowledge of Euro-Western maestro Sergio Leone.