Marquand is most well known as an actor in European films of the '40s, '50s, and '60s, most notably Luchino Visconti's Senso, Roger Vadim's And God Created Woman, and Jacques Tati's Playtime. In the '60s he also began appearing in American films, including Behold a Pale Horse and The Flight of the Phoenix. Marquand directed two films, the romantic drama Les Grands Chemins (aka Of Flesh and Blood), and the all-star erotic satire Candy.